This good practice will share insights and experiences of building close-knit international partnerships. The Amsterdam University of Applied Sciences took the initiative to found U!REKA to enhance the quality of applied sciences and professional education. Collaboration between the six U!REKA partners will focus on an urban agenda of smart cities, innovating regions and a triple helix approach. This good practice will center on conceptual and operational challenges of preferred partnerships and invites you to share your experience and reflect on the suitability of this approach for your own institution.